6230B Time of Flight (TOF) LC/MS

The Agilent 6230 time-of-flight LC/MS (LC/TOF) system allows you to upgrade from unit mass measurements to accurate mass for even more confident compound identification beyond conventional LC/MS detection. You will get full-spectrum data for screening, profiling and identification of small molecules, large biologic compounds, and everything in between. Making the 6230B HPLC TOF ideal for applications like drug development, toxicology, and the analysis of intact proteins.

6230B Time of Flight (TOF) LC MS


  • Reduce false positives with better than 1 ppm mass accuracy.
  • Ensure excellent data quality even for fast UHPLC peaks in high-throughput workflows with data acquisition rates up to 44 spectra/second.
  • Identify compounds based on accurate mass, isotopic abundance, and chemical composition using Find by Formula in MassHunter software.
  • Analyze monoclonal Antibodies (mAb) with high mass accuracy and resolving power for glycoforms and truncation.
  • Characterize large biologic compounds with a broad mass range of up to 20,000 m/z.
  • Separate target compounds from interferences with high-resolution data.
  • Find impurities at extremely low concentrations, using Agilent Jet Stream technology with low picogram on-column sensitivity.
  • Identify trace-level target compounds in the presence of more abundant matrix compounds with up to five orders of in-spectrum dynamic range.
  • Reduce administrative tasks and risks while eliminating the need for LC/MS expertise with intuitive MassHunter Walkup software.
  • Perform untargeted screening with optional fragmentation data using in-source induced dissociation.
  • Go beyond UHPLC separation with support for capillary electrophoresis, SFC, 2D-LC, and even GC-APCI chromatographic interfaces.
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