Triple Quadrupole ICP-MS

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Agilent 9500 Triple Quadrupole ICP-MS

ICP-QQQ Performance. Without the Complexity.

75% of ICP-MS users say interferences affect their ability to get reliable results. 80% say their industry is already moving from single quadrupole to ICP-MS/MS. The barrier has always been perceived complexity expert knowledge, multiple gas supplies, difficult method development.

The Agilent 9500 changes all of that. Built on Agilent’s decade of ICP-QQQ leadership, the 9500 brings true triple quadrupole performance to every laboratory with Air mode, Advanced Helium Mode, and OpenLab ICP-MS software designed to make your first run right, every time.

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Features

  • Proprietary Dual-Cell System (DCS) combines Advanced Helium Mode and Air mode for simple, powerful interference removal across complex sample matrices
  • Advanced Helium Mode replaces multiple tune modes with one streamlined mode, reducing acquisition time by more than 33% for faster routine analysis
  • Air cell uses ambient air for oxygen mass-shift reactions, resolving difficult on-mass interferences while eliminating extra reactive gas infrastructure and related safety concerns
  • DCS with AHM combines Collision-Induced Dissociation (CID) and Kinetic Energy Discrimination (KED) in a single high-performance mode for powerful interference removal while maintaining low mass sensitivity
  • Preset methods, Method Advisor, and automated method conversion tools simplify method setup and make ICP-QQQ more accessible for routine analysis
  • Single quadrupole familiarity with triple quadrupole capability–less to learn, while achieving more
  • Improved hardware design enhances performance and usability, including a new u-lens, Q2 mass range extended to 300 u, and a 0.05 ms minimum dwell time
  • Easy-fit sample introduction, improved accessibility, and ergonomic design simplify installation and maintenance, reducing manual effort and supporting reliable day-to-day operation
  • Integrated Agilent automation options support higher productivity through unattended analysis, automated dilution and calibration, and lower cost per sample
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Applications

Analysis of Waters by ICP-QQQ with a Dual-Cell System and Discrete Sampling

This application note shows how the Agilent 9500 ICP-QQQ with Dual-Cell System in Advanced Helium Mode and AVS MS discrete sampling enables fast, accurate analysis of environmental waters. In a two-hour sequence, 141 samples and QCs were measured in 138 minutes, delivering 50% higher throughput than a comparable single-quad ICP-MS method while maintaining accuracy, stability, and robust performance for high-matrix samples.

Automated Analysis of Foods by ICP-QQQ with Discrete Sampling and Autodilution

This application note shows how the Agilent 9500 ICP-QQQ with Dual-Cell System, AVS MS discrete sampling, and ADS 2 autodilution delivers fast, accurate, AOAC-compliant food analysis. The workflow automates calibration and dilution, removes challenging interferences on As and Se, and improves productivity with analysis times about 30 seconds faster per sample than comparable single-quad ICP-MS methods, while maintaining robust long-term stability.

Direct Analysis of Seawater Using ICP-QQQ and Integrated Advanced Valve System

This application note shows how the Agilent 9500 ICP-QQQ with AVS MS enables direct seawater analysis using online reverse dilution. The robust method achieved ppt-level MDLs for 26 elements, 90–110% recoveries for CRMs and spiked samples, and stable performance over 100 undiluted seawater injections, meeting EPA Method 200.8 QC requirements while simplifying sample prep and supporting high-throughput analysis of heavy matrix samples.

Agilent 9500 ICP-QQQ with m-Lens for Ultratrace Analysis of High-Purity Reagents

This application note shows how the Agilent 9500 ICP-QQQ with optional m-lens delivers ultratrace analysis of high-purity reagents under hot-plasma conditions. Using preset methods for 1% HNO3 and 9.8% H2SO4, the system achieved sub- or single-digit ppt detection limits and low backgrounds across target analytes, including challenging Zn in H2SO4, providing a sensitive, reproducible workflow for semiconductor-grade impurity analysis.

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Agilent 9500 Capability Summary

FeatureWhat It Delivers for Your Lab
Advanced Helium Mode (AHM)Single streamlined mode replacing no-gas, He, and High Energy He. >33% faster. ~20x sensitivity at low masses. CID + KED combined
Air ModeO₂ mass-shift reactions from ambient lab air. Resolves P, S, As, Se, REE²⁺ interferences. No cylinders, no gas cabinet, no HSE overhead.
Dual-Cell System (DCS)Proprietary dual ion guide enabling both AHM and Air mode from a single instrument. High sensitivity across the entire mass range.
Eliminate Re-runs15% of samples typically remeasured in routine labs. AHM + Air mode interference-free results eliminate this cost and time overhead.
OpenLab ICP-MS SoftwareMethod Advisor, pre-set methods, batch conversion from SQ methods. Automated setup to reporting. IntelliQuant for all-mass screening.
True ICP-MS/MS (QQQ)Q1 mass selection → DCS reaction cell → Q2 detection. Controlled, consistent interference removal in MS/MS mode.
Integrated AutomationSPS 4/6 autosampler + AVS MS switching valve + ADS 2 autodilutor. Unattended runs, automated dilution, lower cost per sample.
Compact Footprint65mm shorter than previous generation (11% smaller). W1060 x D600 x H530mm. 20% less power, 50% less exhaust flow.
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